Testbed Facilities for Multi-faceted Testing throughout the Service Development Lifecycle

This paper gives a general overview of the ITIL service lifecycle and problems addressed by experimenters in the different phases of such a process. To address these needs, the ongoing FP7-ICT project TEFIS (Testbed for Future Internet Services) is described and how it seeks to support the requirements of an experimenter by giving access to different testbed-facilities and support tools for test management and planning. Three test scenarios are explained to demonstrate the benefits of the TEFIS multi-faceted testing facility. The question for TEFIS is whether we can support and satisfy the user requirements of service experimenters via a single access point. Finally, suggestions for future extensions and enhancements of the platform are discussed to allow experimenters to design effective tests which involve different resources independent of place and across the entire service development lifecycl

Amplifire: d1.2 fire future structure and Evolution report. Second edition M24: Conclusions and recommendations for fire’s future

This deliverable presents key elements of FIRE’s strategy towards 2020 in the form ofconclusions and recommendations. The work draws from ongoing discussions as well asearlier papers and deliverables, and discussions during events (co-)organised by AmpliFIRE.The conclusions and recommendations are currently being discussed within the FIREcommunity during the months February – March 2015

Future internet research and experimentation: vision and scenarios 2020

The over-all mission of the AmpliFIRE Support Action is to support the FIRE Community to prepare FIRE for 2020, by strengthening the exploitation and impact creation capacities of Future Internet Research and Experimentation (FIRE) facilities. AmpliFIRE vision for year 2020, setting out a transition path from the current situation towards a “FIRE Ecosystem” for 202

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and individuals with APOE4-associated disorders. In mice, lack of Apoe leads to blood-brain barrier (BBB) breakdown, whereas APOE4 increases BBB susceptibility to injury. How APOE genotype affects brain microcirculation remains elusive. Using different APOE transgenic mice, including mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of APOE4 and lack of murine Apoe, but not APOE2 and APOE3, leads to BBB breakdown by activating a proinflammatory CypA-nuclear factor-κB-matrix-metalloproteinase-9 pathway in pericytes. This, in turn, leads to neuronal uptake of multiple blood-derived neurotoxic proteins, and microvascular and cerebral blood flow reductions. We show that the vascular defects in Apoe-deficient and APOE4-expressing mice precede neuronal dysfunction and can initiate neurodegenerative changes. Astrocyte-secreted APOE3, but not APOE4, suppressed the CypA-nuclear factor-κB-matrix-metalloproteinase-9 pathway in pericytes through a lipoprotein receptor. Our data suggest that CypA is a key target for treating APOE4-mediated neurovascular injury and the resulting neuronal dysfunction and degeneration